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KMID : 0356620090240040272
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Journal of Korean Society of Endocrinology
2009 Volume.24 No. 4 p.272 ~ p.276
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A Case of Graves’ Disease with Pancytopenia
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Shin Jong-Ho
Kim Hyun-Jin
Kim Si-Bum
Kim Dong-Pil
Ko Bong-Suk
Kim Dong-Soon
Kim Ji-Myung
Gong Soo-Jung
Lee Jung-Ae
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Abstract
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Hematological disorders, and especially single lineage abnormalities, have been described in patients suffering with thyrotoxicosis, but pancytopenia is a rare complication of thyrotoxicosis. Pancytopenia with thyrotoxicosis has been reported to be totally reversible with antithyroid drug treatment. We experienced a case with pancytopenia associated with Graves’ disease in a 57-year-old woman who had no specific cause of pancytopenia. She presented with dyspnea and palpitation. The laboratory findings revealed thyrotoxicosis and pancytopenia. Increased radioisotope uptake was seen on the thyroid scan and normal cellularity and maturation were found in the bone marrow aspiration biopsy. Based on these findings, she was diagnosed as suffering from Graves´disease with pancytopenia. After treatment with propylthiouracil, the blood cell counts were restored to normal as the patient achieved a euthyroid state. We report here on a case of Graves’ disease that was complicated by pancytopenia, and all this was normalized after treatment for hyperthyroidism.
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KEYWORD
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Graves’ disease, pancytopenia, thyrotoxicosis
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